In:
Brain and Behavior, Wiley, Vol. 7, No. 2 ( 2017-02)
Kurzfassung:
Epilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors ( CRF s), antiepileptic drugs ( AED s), and etiology. Material and Methods A single‐center retrospective epilepsy cohort from the decade of 2004–2013 was assessed. Poisson regression models with robust variance were estimated to obtain CRF prevalence ratios ( PR ) according to AED prescription and etiology. Results After excluding patients in the monotherapy group with vascular etiology or previous cardiovascular events, in the remaining 400 patients, enzyme‐inducer AED s ( EIAED s), especially phenytoin ( PHT ), were associated with higher prevalence of dyslipidemia ( PR a 1.77, p 〈 .05), compared to valproic acid. No etiology was associated with higher prevalence of any CRF . Conclusions Patients treated with EIAED s, especially PHT , had higher prevalence of dyslipidemia.
Materialart:
Online-Ressource
ISSN:
2162-3279
,
2162-3279
DOI:
10.1002/brb3.2017.7.issue-2
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
2623587-0
