In:
Cancer Medicine, Wiley, Vol. 5, No. 5 ( 2016-05), p. 888-891
Abstract:
Barrett's esophagus ( BE ) and esophageal adenocarcinoma ( EAC ) represent two stages within the esophagitis‐metaplasia‐dysplasia‐adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE / EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF 7 (rs3072), TBX 5 (rs2701108), and ALDH 1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE / EAC sequence. Our data show that rs3072 at GDF 7 and rs2701108 at TBX 5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE / EAC sequence. In contrast, rs3784262 at ALDH 1A2 was highly significantly associated with BE , but showed no association with EAC . Our data do not provide evidence that the ALDH 1A2 locus confers equal risk in early and late stages of BE / EAC sequence.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2016.5.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2659751-2