In:
Chemistry & Biodiversity, Wiley, Vol. 14, No. 2 ( 2017-02)
Abstract:
Three new sesquiterpenoids, 4 α ‐hydroxyeudesm‐11(13)‐en‐12‐yl 3‐methylbutanoate ( 1 ), diaspanolide E ( 2 ), and (13 α )‐germacra‐1(10),4‐dien‐12,8 α ‐olid‐15‐oic acid ( 3 ), along with eight known sesquiterpenoids ( 4 – 11 ), were isolated from the aerial parts of Ainsliaea henryi . The chemical structures of compounds 1 – 3 were elucidated by spectroscopic analysis (1D‐, 2D‐ NMR , MS and HR / MS ). All isolates were evaluated for their inhibitory activities against nitric oxide ( NO ) production in lipopolysaccharide‐induced RAW 264.7 macrophage cells. Compound 10 exhibited significantly inhibition against NO release with an IC 50 value of 6.54 ± 0.16 μ m . Also, all isolated compounds were tested for cytotoxicity against three human tumor cell lines A549, MGC 803, and HCT 116, among which compound 5 significantly inhibited the proliferation of MGC 803 cell lines with an IC 50 value of 2.2 ± 0.2 μ m .
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.201600210
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2139001-0
SSG:
12