In:
Chemistry & Biodiversity, Wiley, Vol. 20, No. 2 ( 2023-02)
Kurzfassung:
In this study, eight naphthoquinone derivatives were synthesized in yields ranging from 52 to 96% using easy, fast, and low‐cost methodologies. All naphthoquinone derivatives were screened for their in vitro anti‐proliferative activities against OVCA A2780 cancer cell lines. Amongst all analysed compounds, derivatives 3 – 5 presented the most prominent cytotoxic potential. Naphthoquinones 3 and 4 , bearing sulfur‐containing groups, were identified as having high potential for ROS production, in particular the superoxide anion. Furthermore, 3 and 4 compounds caused a decrease in the cell population in G0/G1 and induced more than 90% of the cell population to apoptosis. Compound 5 did not act in any of these processes. Finally, compounds 3 – 5 were tested for their inhibitory ability against PI3K and MAPK. Compounds 3 and 4 do not inhibit the PI3K enzyme. On the other hand, the naphthoquinone‐polyphenol 5 was only able to inhibit the percentage of cells expressing pERK.
Materialart:
Online-Ressource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202200807
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2023
ZDB Id:
2139001-0
SSG:
12
