In:
Chemistry & Biodiversity, Wiley
Abstract:
Soluble epoxide hydrolase (sEH) inhibitory activity guided fractionation and isolation of two new isocucurbic acid derivatives ( 1 and 2 ) and nine known compounds ( 3 – 11 ) from the flowers of Chrysanthemum indicum L. Their structures were elucidated on the basis of spectroscopic data interpretation and comparison with those reported in previous studies. Luteolin ( 3 ), acacetin‐7‐ O ‐ β ‐D‐glucopyranoside ( 6 ), and methyl 3,4‐di‐ O ‐caffeoylquinate ( 10 ) displayed sEH inhibitory activities with IC 50 values ranging from 13.7±3.6 to 20.8±0.4 μM. Enzyme kinetic analysis revealed that 3 , 6 , and 10 were non‐competitive inhibitors with K i values of 14.8±0.5, 31.2±0.8, and 3.9±0.2 μM, respectively. Additionally, molecular docking studies indicated compound 10 had the ability to form six hydrogen bonds at sEH active site, resulting binding energy as low as −9.58 Kcal/mol.
Type of Medium:
Online Resource
ISSN:
1612-1872
,
1612-1880
DOI:
10.1002/cbdv.202301242
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2139001-0
SSG:
12