In:
Cell Biochemistry and Function, Wiley, Vol. 42, No. 2 ( 2024-03)
Abstract:
In our study, we aimed to answer the question whether the use of linagliptin, a DPP4 inhibitor with high antioxidant activity, and insulin triggers the survival pathway or the apoptotic pathway of unfolded protein response (UPR) signaling activated by endoplasmic reticulum (ER) stress in type 1 diabetes mellitus (T1DM) mouse ovaries to reach new therapeutic targets. Our results showed that the addition of linagliptin to insulin induced pro‐survival UPR by decreasing ATF4 and increasing XBP1s proteins, while suppressing proapoptotic UPR by decreasing p‐JNK1 + JNK2, cleaved caspase 12, and cleaved caspase 3 proteins. This study will contribute to the literature in terms of the discovery of new methods to be used in the treatment of ovarian pathologies associated with diabetes‐induced ER stress.
Type of Medium:
Online Resource
ISSN:
0263-6484
,
1099-0844
Language:
English
Publisher:
Wiley
Publication Date:
2024
detail.hit.zdb_id:
1496553-7
SSG:
12