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Identification and genetic validation of leukemia inhibitory factor super‐enhancers in acute respiratory distress syndrome and lung cancer

Chen, Liuting ; Wang, Lu ; Shao, Yeling ; [weitere]

Wiley ; 2024

In: Cell Biochemistry and Function Vol. 42, No. 4 ( 2024-06)

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In: Cell Biochemistry and Function, Wiley, Vol. 42, No. 4 ( 2024-06)

Kurzfassung: Leukemia inhibitory factor (LIF) is a multifunctional cytokine with diverse functions, playing crucial roles in both acute respiratory distress syndrome (ARDS) and lung cancer development. However, the mechanisms underlying the elevation of LIF in diseases remain largely unclear. In our study, we discovered that basal and LPS‐induced expression of LIF is governed by super‐enhancers. This finding offers novel insights into the transcriptional regulation of LIF expression in the context of ARDS and lung cancer.

Materialart: Online-Ressource

ISSN: 0263-6484 , 1099-0844

URL: Issue

URL: Article

DOI: 10.1002/cbf.v42.4

DOI: 10.1002/cbf.4031

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2024

ZDB Id: 1496553-7

SSG: 12