In:
ChemBioChem, Wiley, Vol. 6, No. 3 ( 2005-03-04), p. 481-490
Abstract:
Looking for a lead . After G protein‐coupled receptors (GPCRs), protein kinases are the second most important class of targets for drug discovery. The 518 protein kinases in the human genome are now regarded as attractive drug targets. Screening for protein kinase inhibitors is therefore expected to become even more important in the future. In this review the early steps of drug discovery programs that produce new lead compounds are described and the reader is guided through efficient state‐of‐the‐art assay development and high‐throughput screening of large chemical libraries for protein kinase inhibitors.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.200400211
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2020469-3
SSG:
12
