In:
ChemBioChem, Wiley, Vol. 21, No. 8 ( 2020-04-17), p. 1201-1205
Abstract:
Although sulfur dioxide (SO 2 ) finds widespread use in the food industry as its hydrated sulfite form, a number of aspects of SO 2 biology remain to be completely understood. Of the tools available for intracellular enhancement of SO 2 levels, most suffer from poor cell permeability and a lack of control over SO 2 release. We report 1,2‐cyclic sulfite diesters as a new class of reliable SO 2 donors that dissociate in buffer through nucleophilic displacement to produce SO 2 with tunable release profiles. We provide data in support of the suitability of these SO 2 donors to enhance intracellular SO 2 levels more efficiently than sodium bisulfite, the most commonly used SO 2 donor for cellular studies.
Type of Medium:
Online Resource
ISSN:
1439-4227
,
1439-7633
DOI:
10.1002/cbic.201900614
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2020469-3
SSG:
12
