In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 88, No. 6 ( 2016-11-15)
Abstract:
Comparative data on long‐term safety and efficacy of bioresorbable‐polymer‐BES versus durable‐polymer‐EES/ZES in ACS setting have hitherto been lacking. We sought to assess the safety and efficacy of bioresorbable‐polymer‐biolimus‐A9‐eluting stents (BES) compared with thin‐strut‐durable‐polymer‐everolimus‐ and zotarolimus‐eluting stents (EES/ZES) in patients with acute coronary syndrome (ACS) undergoing PCI. Methods and Results Between 2007 and 2012, 1,547 patients were implanted with new‐generation drug‐eluting stents (DES). Out of these, 369 received BES and 1,178 EES/ZES. The primary endpoint was probable/definite stent thrombosis (ST) while the secondary endpoint was a composite of all‐cause death, myocardial infarction (MI), target vessel revascularization (TVR) and definite ST up to 5 years. As stent assignment was not random, we performed a propensity score matching (PSM), with 1:3 ratio, to account for potential confounders. Primary analysis demonstrated no significant differences between both groups for the primary endpoint of ST (BES vs. EES/ZES: 1.6% vs. 1.9%; mean‐event‐time = 1,797 days vs. 1,795 days, respectively; P = 0.75) and composite safety endpoint (BES vs. EES/ZES: 12.5% vs. 12.9%; mean‐event‐time = 1,631 days vs. 1,620 days, respectively; P = 0.88). Results regarding the 5‐year‐ST‐ and safety endpoint remained non‐significant after PSM ( P = 0.85, P = 0.56; respectively). After stratification based on cardiovascular risk, no difference regarding ST and composite outcome measure has been documented between both stent groups in high‐risk‐ and low‐risk patients. The type of stent did neither predict ST (HR 1.11, 95%CI 0.45–2.74, P = 0.82) nor composite safety endpoint (HR 0.93, 95%CI 0.67–1.30, P = 0.69). Conclusions Long‐term safety and efficacy of bioresorbable‐polymer‐BES and durable‐polymer‐EES/ZES appear comparable in patients with ACS. © 2016 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2001555-0