In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 98, No. 7 ( 2021-12), p. 1404-1412
Abstract:
To investigate whether the integrative echocardiographic criteria used in the cardiovascular outcomes assessment of the mitraclip percutaneous therapy (COAPT) for heart failure patients with functional mitral regurgitation study predict outcomes after edge‐to‐edge trancatheter mitral valve repair (TMVr) for the treatment of secondary mitral regurgitation (SMR). Background Two randomized controlled trials comparing TMVr to medical treatment reported conflicting findings. Differences in patient selection criteria may have contributed to these diverging results. Methods Patients undergoing TMVr were stratified following the integrative COAPT echocardiographic criteria in noneligible and eligible patients who were further classified into three tiers according to effective regurgitant orifice (EROA) (Tier 1: EROA ≥ 0.3cm 2 ; Tier 2: EROA 0.2cm 2 and 0.29cm 2 ; Tier 3: EROA 〈 0.2cm 2 ) combined with several other severity criteria. We assessed between group differences in all‐cause mortality, successful SMR reduction, and symptom relief from baseline to 2‐year follow‐up. Results Between March 2011 and March 2018, 138 patients (mean age 75 years) satisfying the inclusion criteria underwent TMVr for treatment of symptomatic SMR. The mean EROA area was 0.35 ± 0.17 mm 2 . Ten patients (7%) died within 30 days, 29 (21%) within 12 months, and 41 (30%) within 2 years. After stratification according to the COAPT echocardiographic criteria that were fulfilled in 72% of the studied population, Tier 2 patients (45%), as well as noneligible patients (38%) had a higher mortality rate compared to those in Tier 1 (19%). Conclusions SMR patients stratified into tiers according to the COAPT integrative echocardiographic criteria have diverging prognostic and symptomatic benefit after edge‐to‐edge TMVr.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2001555-0
