In:
ChemCatChem, Wiley, Vol. 10, No. 3 ( 2018-02-07), p. 515-519
Abstract:
The NADP(H)‐dependent reductive aminase from Aspergillus oryzae ( Asp RedAm) was combined with an NADPH oxidase (NOX) to develop a redox system that recycles the co‐factor. The Asp RedAm‐NOX system was applied initially for the kinetic resolution of a variety of racemic secondary and primary amines to yield S ‐configured amines with enantiomeric excess ( ee ) values up to 99 %. The addition of ammonia borane to this system enabled the efficient deracemization of racemic amines, including the pharmaceutical drug rasagiline and the natural product salsolidine, with conversions up to 〉 98 % and 〉 99 % ee Furthermore, by using the Asp RedAm W210A variant it was possible to generate the opposite R enantiomers with efficiency comparable to, or even better than, the wildtype Asp RedAm.
Type of Medium:
Online Resource
ISSN:
1867-3880
,
1867-3899
DOI:
10.1002/cctc.201701484
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2501161-3
