In:
Chemistry – A European Journal, Wiley, Vol. 23, No. 65 ( 2017-11-21), p. 16447-16451
Abstract:
A direct asymmetric vinylogous aldol reaction of nonactivated natural α‐angelica lactone to isatins has been developed. With a N , N′ ‐dioxide‐Sc(OTf) 3 complex as catalyst, a variety of δ‐hydroxy butenolides bearing congested adjacent tetrasubstituted stereocenters were obtained in good yields with high diastereoselectivities and excellent enantioselectivities. Besides, a possible transition state was proposed to explain the origin of the asymmetric induction.
Type of Medium:
Online Resource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201704100
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
1478547-X