In:
Chemistry – A European Journal, Wiley, Vol. 25, No. 65 ( 2019-11-22), p. 14850-14857
Kurzfassung:
Studies carried out in recent decades have revealed that the ability to self‐assemble is a widespread property among biomolecules. Small nucleic acid moieties or very short peptides are able to generate intricate assemblies endowed with remarkable structural and spectroscopic properties. Herein, the structural/spectroscopic characterization of aggregates formed by nucleobases and peptide nucleic acid (PNA)–peptide conjugates are reported. At high concentration, all studied nucleobases form aggregates characterized by previously unreported fluorescence properties. The conjugation of these bases, as PNA derivatives, to the dipeptide Phe–Phe leads to the formation of novel hybrid assemblies, which are characterized by an amyloid‐like association of the monomers. Although these compounds share the same basic cross‐β motif, the nature and number of PNA units have an important impact on both the level of structural order and the intrinsic fluorescence of the self‐assembled nanostructure.
Materialart:
Online-Ressource
ISSN:
0947-6539
,
1521-3765
DOI:
10.1002/chem.201902709
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
1478547-X