In:
Chirality, Wiley, Vol. 26, No. 1 ( 2014-01), p. 21-26
Abstract:
Hydroxyamide‐based ligands have occupied a considerable place in asymmetric synthesis. Here we report the synthesis of seven β‐hydroxyamide‐based ligands from the reaction of 2‐hydroxynicotinic acid with chiral amino alcohols and test their effect on the enantioselective reduction of aromatic prochiral ketones with borane in tetrahydofuran (THF). They produce the corresponding secondary alcohols with up to 76% enantiomeric excess ( ee ) and good to excellent yields (86‐99%). Chirality 26:21–26, 2013 . © 2013 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
0899-0042
,
1520-636X
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2001237-8
SSG:
12
SSG:
15,3