In:
Chinese Journal of Chemistry, Wiley, Vol. 36, No. 1 ( 2018-01), p. 25-30
Abstract:
Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of 19 F magnetic resonance imaging ( 19 F MRI) and fluorescence imaging (FI) into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne‐terminated fluorinated copolymer (P n ) of 2,2,2‐trifluoroethyl acrylate (TFEA) and poly(ethylene glycol) methyl ether acrylate (PEGA) was first prepared via atom transfer radical polymerization (ATRP). The PEGA plays an important role in both improving 19 F signal and modulating the hydrophilicity of P n . The alkynyl tail in P n is readily conjugated with azide modified tetra‐phenylethylene (TPE) through click chemistry to form azo polymer (TPE‐azo‐P n ). The core‐shell nanoprobes (TPE‐P3N) with an average particle size of 57.2 ± 8.8 nm are obtained via self‐assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good 19 F MRI performance, which present great potentials for simultaneous fluorescence imaging and 19 F–MR imaging.
Type of Medium:
Online Resource
ISSN:
1001-604X
,
1614-7065
DOI:
10.1002/cjoc.201700382
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2144352-X
SSG:
6,25
