In:
Clinical Cardiology, Wiley, Vol. 41, No. 8 ( 2018-08), p. 1055-1061
Abstract:
Aim of this study was to evaluate the predictors of hs‐cTnT in a non‐ACS patient cohort admitted to the emergency department. Hypothesis Atrial fibrillation and hypertension may not always be sufficient for elevation for hs‐cTnT. Methods We performed a retrospective, single center study encompassing in total 1003 patients. Individuals were retrospectively divided in ACS‐ and non‐ACS patients by two independent investigators reviewing the medical records. In order to identify predictors of hs‐cTnT elevation hazard ratios were calculated for age, gender, vital signs, cardiovascular risk factors, LVEF, serum levels of CRP, hemoglobin, and creatinine. Elevation of hs‐cTnT was defined by exceeding 14 ng/L (upper reference limit [URL]). Results About 987 patients were included while 25 patients were excluded because of missing data. 307 patients (31.4%) met the current guideline requirements of diagnosing an ACS, whereas 671 patients (68.6%) were hospitalized with excluded ACS. In the multivariate analysis age, anemia, CRP, creatinine, and reduced systolic left ventricular ejection fraction were independent predictors of elevated troponin T levels in the non‐ACS group. However, hypertensive systolic blood pressure, atrial fibrillation and tachycardia were not predictive for Troponin T elevation in non‐ACS patients in this multivariate analysis. Conclusions In an unselected, non‐ACS patient cohort age, chronic renal failure, inflammatory state, and reduced left ventricular systolic function were associated with hs‐cTnT levels above the upper reference limit. Rather, often supposed predictors as atrial fibrillation, hypertension, and tachycardia cannot sufficiently explain increased hs‐cTnT in our study. Hence, further studies are needed to assess whether isolated hypertension, tachycardia, or atrial fibrillation sufficiently explain elevated hs‐cTnT.
Type of Medium:
Online Resource
ISSN:
0160-9289
,
1932-8737
DOI:
10.1002/clc.2018.41.issue-8
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2048223-1
