KOBV-Portal

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Alles auswählen Exportieren

Online-Ressource

Structure‐Based Optimization of Benzoic Acids as Inhibitors of Protein Tyrosine Phosphatase 1B and Low Molecular Weight Protein Tyrosine Phosphatase

Maccari, Rosanna ; Ottanà, Rosaria ; Ciurleo, Rosella ; [weitere]

Wiley ; 2009

In: ChemMedChem Vol. 4, No. 6 ( 2009-06-08), p. 957-962

zur Merkliste hinzufügen auf der Merkliste

Details

In: ChemMedChem, Wiley, Vol. 4, No. 6 ( 2009-06-08), p. 957-962

Kurzfassung: We have optimized previously discovered benzoic acids 1 , which are active as inhibitors of PTP1B and LMW‐PTP, two protein tyrosine phosphatases that have emerged as attractive targets for the development of novel therapeutic agents for the treatment of diabetes, obesity, and cancer. Our efforts led to the identification of new and more potent analogues with appreciable selectivity toward human PTP1B and the IF1 isoform of human LMW‐PTP. magnified image

Materialart: Online-Ressource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v4:6

DOI: 10.1002/cmdc.200800427

RVK:

VA 3569

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2009

ZDB Id: 2209649-8