In:
Contrast Media & Molecular Imaging, Wiley, Vol. 8, No. 1 ( 2013-01), p. 40-49
Abstract:
A novel synthetic methodology for preparing amide conjugates of the DO3A‐ N ‐( α ‐amino)propionate chelator is described, using the synthesis of the DO3A‐ N ‐( α ‐benzoylamido)propionate chelator as an illustrative example. The model Gd[DO3A‐ N ‐( α ‐benzoylamido)propionate] chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn 2+ . The Gd[DO3A‐ N ‐( α ‐benzoylamido)propionate] complex is mainly excreted via the kidneys, producing a significant increase in the kidney medulla/cortex enhancement ratio in MR images of Wistar rats, reflecting probably its higher lipophilicity compared with Gd(DTPA). The results presented suggest that Gd[DO3A‐ N ‐( α ‐amido)propionate] chelates can be valuable leads for preparing potentially safe high relaxivity MRI contrast agents. Copyright © 2012 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
1555-4309
,
1555-4317
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2222967-X