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Docetaxel plus oral metronomic cyclophosphamide: A phase II study with pharmacodynamic and pharmacogenetic analyses in castration‐resistant prostate cancer patients

Derosa, Lisa ; Galli, Luca ; Orlandi, Paola ; [et al.]

Wiley ; 2014

In: Cancer Vol. 120, No. 24 ( 2014-12-15), p. 3923-3931

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In: Cancer, Wiley, Vol. 120, No. 24 ( 2014-12-15), p. 3923-3931

Abstract: The present multicenter, prospective, non‐randomized phase II clinical study demonstrates that the combination of docetaxel and prednisone plus metronomic cyclophosphamide and celecoxib is effective as a first‐line treatment in patients with mCRPC, and that it shows favorable toxicity. Moreover, the investigation of ‐1154A/G VEGF polymorphism, and of VEGF and bFGF plasma levels after the first cycle of chemotherapy suggests that these pharmacodynamic indices may be useful markers to predict a better outcome.

Type of Medium: Online Resource

ISSN: 0008-543X , 1097-0142

URL: Issue

URL: Article

DOI: 10.1002/cncr.v120.24

DOI: 10.1002/cncr.28953

Language: English

Publisher: Wiley

Publication Date: 2014

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