In:
Cancer, Wiley, Vol. 121, No. 8 ( 2015-04-15), p. 1195-1203
Kurzfassung:
In an analysis of a large series of genetically annotated, metastatic colorectal cancer cases, we find that patients whose tumors harbor a RAS mutation experience shorter overall survival and a significantly higher cumulative incidence of brain, bone, and lung metastases, while the presence of a PIK3CA mutation does not predict for worse outcomes or a site‐specific pattern of metastatic spread. These data suggest a role for RAS activation in tumor metastatic progression and may help inform physicians' assessment of symptoms in patients with metastatic colorectal cancer.
Materialart:
Online-Ressource
ISSN:
0008-543X
,
1097-0142
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
1479932-7
ZDB Id:
2599218-1
ZDB Id:
2594979-2
ZDB Id:
1429-1