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Biomarker‐driven phase 2 umbrella trial study for patients with recurrent small cell lung cancer failing platinum‐based chemotherapy

Park, Sehhoon ; Shim, Joonho ; Mortimer, Peter G. S. ; [weitere]

Wiley ; 2020

In: Cancer Vol. 126, No. 17 ( 2020-09), p. 4002-4012

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In: Cancer, Wiley, Vol. 126, No. 17 ( 2020-09), p. 4002-4012

Kurzfassung: To the authors' knowledge, the current study is the first biomarker‐driven umbrella study in patients with recurrent and refractory small cell lung cancer (SCLC) using adavosertib, vistusertib, and AZD2811NP. Although the overall outcome of this study fails to satisfy the primary endpoint, the results provide the rationale to focus on the exploration of combination approaches for the treatment of patients with recurrent and refractory SCLC.

Materialart: Online-Ressource

ISSN: 0008-543X , 1097-0142

URL: Issue

URL: Article

DOI: 10.1002/cncr.v126.17

DOI: 10.1002/cncr.33048

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2020

ZDB Id: 1479932-7

ZDB Id: 2599218-1

ZDB Id: 2594979-2