In:
Cancer, Wiley, Vol. 128, No. 6 ( 2022-03-15), p. 1206-1218
Abstract:
This study suggests prognostic significance of Lynch‐like cancers versus sporadic microsatellite instability–high (MSI‐H) endometrial cancers (ECs) for the objective response rate, progression‐free survival, and overall survival when patients are treated with pembrolizumab. Defective antigen processing/presentation and deranged induction in interferon responses serve as mechanisms of resistance in sporadic MSI‐H ECs, and clinical studies evaluating separate MSI‐H EC subtypes treated with immune checkpoint inhibitors are warranted.
Type of Medium:
Online Resource
ISSN:
0008-543X
,
1097-0142
Language:
English
Publisher:
Wiley
Publication Date:
2022
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1479932-7
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2599218-1
detail.hit.zdb_id:
2594979-2
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1429-1