In:
Drug Development Research, Wiley, Vol. 14, No. 3-4 ( 1988-01), p. 205-211
Abstract:
A new technique has been utilized to assess quantitatively the filterability (i.e., the ability to pass restricted pores) of leukocyte‐free red blood cell (RBC) suspensions by means of computer‐assisted conductometry of novel precision metal microsieves with uniform pore diameters of 4.2 μm (MyNiPore®). RBCs were exposed to adverse conditions of chemical “stress” (400 mOsmol/liter, pH 6.8), thereafter, the effects of vinpocetine (Methyl‐Apo‐Vipamin, Thiemann‐Arzneimittel GmbH, Waltrop, FRG) were tested. When added in concentrations between 10 −5 and 10 −2 mol/liter to the “stressed” RBCs, vinpocetine restored the red cell microrheological performance (or behavior) when tested under low shear stresses. The present results suggest that in interpreting vinpocetine's effects in low flow situations, a possible protective microrheological action should be taken into consideration.
Type of Medium:
Online Resource
ISSN:
0272-4391
,
1098-2299
DOI:
10.1002/ddr.430140309
Language:
English
Publisher:
Wiley
Publication Date:
1988
detail.hit.zdb_id:
1500191-X
SSG:
15,3