In:
European Journal of Immunology, Wiley, Vol. 25, No. 5 ( 1995-05), p. 1319-1325
Abstract:
The age‐related changes in the function of antigen‐presenting cells (APC) were examined using a substrain of senescence‐accelerated mouse (SAMP1). In the primary mixed lymphocyte reaction (MLR), dendritic cells (DC) from aged SAMP1 mice showed less stimulatory activity than those of age‐matched BALB/c or young SAMP1 mice. In the secondary MLR, the stimulatory activity of B cells was found to be lower in aged SAMP1 mice but not in age‐matched BALB/c or young SAMP1 mice. In addition, these age‐related decreases in the stimulatory activity of APC were found to be related to changes in the surface density of major histocompatibility complex class II and intercellular adhesion molecule‐1 (ICAM‐1) (but not B7‐1 or B7‐2 molecule) on APC (DC and B cells).
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.1830250528
Language:
English
Publisher:
Wiley
Publication Date:
1995
detail.hit.zdb_id:
1491907-2
