In:
European Journal of Immunology, Wiley, Vol. 42, No. 4 ( 2012-04), p. 831-841
Kurzfassung:
T‐cell activation and the subsequent transformation of activated T cells into T ‐cell blasts require profound changes in cell volume. However, the impact of cell volume regulation for T ‐cell immunology has not been characterized. Here we studied the role of the cell‐volume regulating osmolyte transporter T aut for T ‐cell activation in T aut‐deficient mice. T‐cell mediated recall responses were severely impaired in taut −/− mice as shown with B 16 melanoma rejection and hapten‐induced contact hypersensitivity. CD4 + and CD8 + T cells were unequivocally located within peripheral lymph nodes of unprimed taut −/− mice but significantly decreased in taut −/− compared with taut +/+ mice following in vivo activation. Further analysis revealed that T aut is critical for rescuing T cells from activation‐induced cell death in vitro and in vivo as shown with TCR , superantigen, and antigen‐specific activation. Consequently, reduction of CD4 + and CD8 + T cells in taut −/− mice upon antigen challenge resulted in impaired in vivo generation of T ‐cell memory. These findings disclose for the first time that volume regulation in T cells is an element in the regulation of adaptive immune responses and that the osmolyte transporter T aut is crucial for T ‐cell survival and T ‐cell mediated immune reactions.
Materialart:
Online-Ressource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201141690
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2012
ZDB Id:
1491907-2