In:
European Journal of Immunology, Wiley, Vol. 49, No. 6 ( 2019-06), p. 966-968
Abstract:
It is a matter of current debate whether the bone marrow is a hub for circulating memory T lymphocytes and/or the home of resident memory T lymphocytes. Here we demonstrate for CD69 + murine CD8 + , and CD69 + murine and human CD4 + memory T lymphocytes of the bone marrow, making up between 30 and 60% of bone marrow memory T lymphocytes, that they express the gene expression signature of tissue‐resident memory T lymphocytes. This suggests that a substantial proportion of bone marrow memory T lymphocytes are resident. It adds to previous evidence that bone marrow memory T cells are resting in terms of mobility and proliferation, and maintain exclusive long‐term memory to distinct, systemic antigens.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201847982
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1491907-2
