In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2012, No. 16 ( 2012-06), p. 2828-2837
Kurzfassung:
Bimodal magnetic resonance imaging (MRI)/optical probes for bioimaging were obtained by grafting two types of lanthanide metal ions, Gd 3+ and Eu 3+ /Tb 3+ , on the surface of SiO 2 nanoparticles. The resulting systems were endowed with relaxometry and photoluminescent properties, respectively. Grafting a pyridine‐based aromatic backbone on to the silica surface enhances the emission quantum yield of the Eu 3+ ‐containing nanoparticles fivefold compared to similar systems that bear no aromatic antennae. The emission properties of the mixed Ln 3+ /Gd 3+ ‐based nanoparticles are not influenced by the presence of Gd 3+ . The relaxometric properties of these samples are slightly better than the properties of commercial [Gd(DTPA)] 2 (DTPA = diethylenetriaminepentaacetate). When taken up by RAW 264.7 cells (mouse macrophage cell line), such bimodal probes exhibit both T 1 ‐weighted MRI increased contrast and fluorescence tracking.
Materialart:
Online-Ressource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2012.16
DOI:
10.1002/ejic.201101110
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2012
ZDB Id:
1475009-0
