In:
European Journal of Inorganic Chemistry, Wiley, Vol. 2015, No. 4 ( 2015-02), p. 725-733
Abstract:
Two new homo‐ and heteroleptic bismuth thiazole‐thiolato complexes derived from 4‐phenylthiazole‐2‐thiol MBT(H) have been synthesised and structurally characterised, [BiPh(MBT) 2 ] 2 and [Bi(MBT) 3 ] 2 . Syntheses were achieved using BiPh 3 or Bi(O t Bu) 3 in protolysis reactions with MBT(H), or by salt metathesis with BiCl 3 or BiPhCl 2 and the sodium thiolate, [NaMBT]. The complexes were obtained under both standard solvent‐free and solvent‐mediated conditions, and by microwave irradiation. The solid‐state structures of [BiPh(MBT) 2 ] 2 and [Bi(MBT) 3 ] 2 , were determined using single‐crystal X‐ray diffraction, showing them to be dimeric. The bactericidal properties of the complexes against Mycobacterium smegmatis, Staphylococcus aureus , methicillin‐resistant Staphylococcus aureus (MRSA), Enterococcus faecalis , vancomycin‐resistant Enterococcus (VRE) and Escherichia coli revealed [BiPh(MBT) 2 ] 2 to be the most effective against all the bacteria with MIC values of 0.6 μg/mL (0.25 μ M ) against S. aureus and 0.9 μg/mL (0.27 μ M ) against E. faecalis . [Bi(MBT) 3 ] 2 was less active overall. However, comparisons with the analogous complex [Bi(4‐BrMTD) 3 ], revealed a significant hundred‐fold enhanced activity against S. aureus , MRSA, VRE, and E. faecalis . Both complexes showed little or no toxicity towards mammalian COS‐7 cells at 20 μg/mL. [BiPh(MBT) 2 ] 2 also was found to display good antileishmanial activity with an IC 50 value of 0.11 μg/mL (0.17 μ M ), at which concentration the complex was non‐toxic to human fibroblast cells.
Type of Medium:
Online Resource
ISSN:
1434-1948
,
1099-0682
DOI:
10.1002/ejic.v2015.4
DOI:
10.1002/ejic.201402958
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1475009-0
