In:
European Journal of Organic Chemistry, Wiley, Vol. 2018, No. 32 ( 2018-08-31), p. 4431-4435
Abstract:
A transition metal‐free approach was developed to achieve substituted furocoumarins via an iodine‐promoted one‐pot cyclization between 4‐hydroxycoumarins and acetophenones. High yields of furocoumarins were achieved in the presence of NH 4 OAc as an additive, while neither acidic nor basic additives were effective. The reaction would proceed via a 5‐exo‐tet cyclization but not an O‐alkylation. The fact that commercially available starting materials could be used without the need of a transition metal catalyst could be a significant advantage.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2018.32
DOI:
10.1002/ejoc.201800983
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475010-7