In:
European Journal of Organic Chemistry, Wiley
Abstract:
An efficient three‐component synthesis of 4‐aryl‐2‐aminothiazoles was reported. Phenyl‐thioureas reacted with 2‐bromoacetophenones to form 4‐aryl‐2‐aminothiazoles through cyclization, and the subsequent C−N bonding with benzyl/allyl bromides gave the desired disubstituted thiazoles smoothly. The protocol features transition‐metal free, short reaction time, easily available starting materials, good yields and broad substrate scope, showing potential synthetic value for the synthesis of a variety of biologically or pharmaceutically active compounds.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.202300817
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
1475010-7