In:
Electroanalysis, Wiley, Vol. 30, No. 12 ( 2018-12), p. 2853-2860
Abstract:
Thermosensitive microgel particles based on the polymeric network synthesized from N ‐isopropylacrylamide, sodium acrylate and N , N′ ‐bisacryloylcystine have been functionalized with aminoferrocene, a mediatior, and a model enzyme‐glucose oxidase (GOx). The product was very stable. A thin coating of that material has been successfully attached to the glassy carbon electrode surface to form a sensing layer. A temperature increase to a value higher than the volume phase transition temperature led to a substantial increase in the amperometric signal. That behavior was well switchable. The amperometric signal was linearly dependent on glucose concentration in the physiological concentration range. It appeared that the synthesized and functionalized microgel was a kind of microreactor and might be very useful for the construction of the platforms that can enhance the activity of enzymes in biosensors.
Type of Medium:
Online Resource
ISSN:
1040-0397
,
1521-4109
DOI:
10.1002/elan.201800459
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1483564-2