In:
Head & Neck, Wiley, Vol. 38, No. S1 ( 2016-04)
Kurzfassung:
Few studies have investigated the effect of vitamin E in reducing the cisplatin (CDDP)‐induced ototoxicity. This study evaluated vitamin E supplementation as a protecting agent against CDDP‐induced ototoxicity. Methods Patients who started CDDP were randomly assigned to receive vitamin E supplementation at 400 mg per day (group 1) or placebo (group 2). Audiograms and evoked brainstem responses were obtained at baseline, and after 1, 2, and 3 months. Results Twenty‐three patients affected by solid malignancies were enrolled (13 in group 1 and 10 in group 2). At 1 month, a significant hearing loss in group 2 at both 2000 HZ (right ear: p = .05; left ear: p = .04) and 8000 HZ (right ear: p = .04; left ear: p = .03) was detected when compared to baseline values. Audiograms did not show significant changes. At 1 month, evoked brainstem responses remained unchanged in both arms without significant differences between groups. Conclusion These preliminary findings confirm the neuroprotective properties of vitamin E against the CDDP‐induced ototoxicity. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E2118–E2121, 2016
Materialart:
Online-Ressource
ISSN:
1043-3074
,
1097-0347
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2001440-5