In:
Helvetica Chimica Acta, Wiley, Vol. 75, No. 5 ( 1992-08-13), p. 1639-1650
Abstract:
The synthesis of 4‐(methylthio)‐1 H ‐imidazo[4,5‐ c ]pyridine 2′‐deoxy‐β‐ D ‐ribonucleosides 2 and 9 and the conversion of the N 1 ‐isomer 2 into the 2′,3′‐didehydro‐2′,3′‐dideoxyribonucleoside 3a or ( via 7 ) 3‐deaza‐2′‐deoxyadenosine ( 1 ) is described. Phosphonate building blocks of 1 were employed in solid‐phase synthesis of self‐complementary base‐modified oligonucleotides. Their properties were studied with regard to duplex stability and hydrolysis by the restriction enzyme Eco RI.
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.19920750519
Language:
English
Publisher:
Wiley
Publication Date:
1992
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2