In:
Helvetica Chimica Acta, Wiley, Vol. 77, No. 3 ( 1994-05-11), p. 631-644
Abstract:
A series of 2′‐benzamido‐2′‐deoxyadenosine analogues were synthesized in an effort to find new lead structures for the treatment of sleeping sickness. The 2′‐deoxy‐2′‐(3‐methoxybenzamido)adenosine ( 1h ) was proved to be a selective inhibitor of the parasite glyceraldehyde 3‐phosphate dehydrogenase which confirms the modeling studies. The solution‐state conformation of 2′‐(thiophene‐2‐carboxamido) analogue 1d demonstrates a 2′‐ endo conformation, an orientation of the thiophene ring under the ribose moiety, and the base part occupying a ‘ syn ’/‘ anti ’ equilibrium.
Type of Medium:
Online Resource
ISSN:
0018-019X
,
1522-2675
DOI:
10.1002/hlca.19940770306
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
74-7
detail.hit.zdb_id:
1475013-2