In:
International Journal of Cancer, Wiley, Vol. 133, No. 4 ( 2013-08-15), p. 908-919
Abstract:
What's new? Elevated expression of neurotrophic tyrosine kinase type 1 receptor (NTRK1, or TrkA) previously was found to be associated with favorable prognosis in neuroblastoma. That effect may be the result of TrkA‐induced enhancement of the immune response toward neuroblastoma cells, as reported here. The findings suggest that TrkA‐associated immune activity might partly explain spontaneous regression of low‐stage neuroblastomas. They also have novel translational implications, among them the possibility for the development of T cell‐based immunotherapy approaches.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8