In:
International Journal of Cancer, Wiley, Vol. 134, No. 2 ( 2014-01-15), p. 376-383
Abstract:
What's new? Many patients with colon carcinoma experience recurrence of the cancer after treatment and it remains unclear how to properly predict treatment success. Here, the authors used a combinatorial approach to search for biomarkers that correlate with survival. They found that a combination of low levels of urinary 8‐oxo‐7,8‐dihydroguanine either with low levels of 8‐oxo‐7,8‐dihydro‐2'‐deoxyguanosine in leukocyte DNA or with high levels of uric acid in blood plasma had significant predictive power for the prognosis of colorectal cancer, comparable to conventional staging procedures. Both combinations represent markers of the oxidative stress/DNA damage pathway, which in combination with clinical staging may be used to identify high‐risk groups of patients to improve personalized treatment options.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
