In:
International Journal of Cancer, Wiley, Vol. 134, No. 4 ( 2014-02), p. 849-858
Abstract:
What's new? Here the authors describe the complex role of the oxygen sensor PHD2 in tumor‐associated immune cells in a conditional PHD2‐deficient mouse line. They demonstrate that the observed reduced tumor volume is a consequence of opposing changes including the drastic down‐regulation of numerous pro‐ as well as anti‐tumoral genes and an imbalance between enhanced cell death and greater proliferation of tumor cells. They confined this complex phenotype to the crosstalk of PHD2‐deficient myeloid cells and T‐lymphocytes. The findings reveal a multifaceted role for PHD2 in hematopoietic lineages during tumor development and might have important implications for the development of tumor therapies.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
