In:
International Journal of Cancer, Wiley, Vol. 134, No. 11 ( 2014-06), p. 2547-2559
Kurzfassung:
What's new? Intrabodies are antibodies that have been engineered to be expressed within cells, in order to selectively interfere with cellular processes. In this study, the authors designed a bispecific, membrane‐anchored intrabody with domains that interact both with extracellular and intracellular epitopes of EGFR. When it was expressed in EGFR‐dependent tumor cells, EGFR surface levels, ligand‐induced autophosphorylation, and tumor‐cell growth were all reduced, demonstrating functionality of this novel type of intrabody in tumor cells.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
218257-9
ZDB Id:
1474822-8
