In:
International Journal of Cancer, Wiley, Vol. 135, No. 1 ( 2014-07), p. 61-68
Kurzfassung:
What's New? Hepatocellular carcinoma (HCC) is caused by a complex interplay between genetic and environmental factors. Hepatitis B virus (HBV) infection is a frequent cause of HCC, and there is accumulating evidence that single nucleotide polymorphisms (SNPs) are also associated with risk of HCC. Because ATF6 is an important modulator of the unfolded protein response (UPR), which is involved in carcinogenesis, here the authors speculated that SNPs in ATF6 may be associated with susceptibility to HCC. Using a 2‐stage association study, they found a missense polymorphism that was strongly associated with HBV‐related HCC and may contribute to susceptibility by altering ATF6 expression.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
218257-9
ZDB Id:
1474822-8
