In:
International Journal of Cancer, Wiley, Vol. 135, No. 1 ( 2014-07), p. 117-127
Abstract:
What's New? The identification of novel genes that are hypermethylated in cancer and precancerous lesions is needed in order to achieve a better sensitivity and specificity in cervical cancer screening. Using a genome‐wide approach, here the authors identified 14 genes that were frequently hypermethylated in CIN3+ and might thus become useful biomarkers in future molecular cervical cancer screening. A bioinformatics function analysis revealed that five of these genes were potentially implicated in β‐catenin signaling, suggesting the epigenetic dysregulation of Wnt signaling during cervical cancer development. The concurrent hypermethylation of multiple genes also suggests the involvement of a CpG island methylator phenotype.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
