In:
International Journal of Cancer, Wiley, Vol. 135, No. 4 ( 2014-08-15), p. 809-819
Abstract:
What's new? The oncogene SOX2 is overexpressed in lung cancer. To find out how it contributes to cancer development, these authors investigated which genes were affected by silencing SOX2. They discovered that a lack of SOX2 significantly boosted the expression of the gene BMP4. As a member of the TGF‐β family, BMP4 seemed a good candidate for a key player in the cancer process. Further investigation revealed that tumor cells contain less BMP4, and that reactivation of BMP4 could slow tumor growth and halt cell proliferation. These findings may explain how SOX2 promotes tumor development.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8