In:
International Journal of Cancer, Wiley, Vol. 136, No. 4 ( 2015-02-15), p. 797-809
Kurzfassung:
What's new? A number of proteins that are involved in tumorigenesis are influenced by the protein kinase CK2, and the expression of CK2α specifically is known to be modified in certain cancers, suggesting possible effects on tumor development and progression. The present study indicates that CK2α is an independent prognostic indicator of gastric carcinoma and is involved in tumorigenesis by regulating the phosphorylation of the potentially oncogenic protein DBC1 (deleted in breast cancer 1). Inhibition of CK2α or DBC1 attenuated proliferation and invasion activity of cancer cells, suggesting that the CK2α‐DBC1 pathway may be a therapeutic target for gastric carcinoma.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
218257-9
ZDB Id:
1474822-8