In:
International Journal of Cancer, Wiley, Vol. 136, No. 6 ( 2015-03-15), p. 1254-1262
Abstract:
What's New? Genetic damage in utero can pave the way for cancer later in life. Why are younger animals more susceptible to carcinogens than adults? In this paper, the authors quantify this effect for the first time. They exposed fetal mice to aflatoxin and compared the rates of cancer‐causing mutations with adult mice exposed to the same dose of aflatoxin. The DNA adducts created were 20‐fold more likely to cause mutations in liver cells in the young mice than in the adults. Not surprisingly, they observed that fetal liver cells were dividing much faster than adult liver cells, providing evidence for the view that rapid cell division creates this youthful susceptibility to carcinogens.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8