In:
International Journal of Cancer, Wiley, Vol. 57, No. 1 ( 1994-04), p. 21-25
Abstract:
Loss of heterozygosity at 4 tumor‐suppressor gene loci ( p53 , apc , mcc and Rb ) was investigated using polymerase chain reactions, in 49 esophageal squamous‐cell carcinoma specimens from patients who had undergone curative resection. Mutations in the p53 gene within exons 5 to 8 were also examined. LOH was detected in 9 (43%) of 21 p53 genes, 16 (55%) of 29 apc genes, 10 (48%) of 21 mcc genes, and 13 (52%) of 25 Rb genes for which heterozygosity could be determined. Mutations in the p53 gene were detected in 18 (36%) of 49 cases and were significantly more frequent in stage‐III tumors and in tumors exhibiting DNA aneuploidy. In 5 cases where heterozygosity could be determined for all the loci, all had 2 or more aberrations. Additionally, a heterozygous deletion of p53 gene was associated with a mutation of the remaining allele in 8 (89%) of 9 cases. Short‐term relapse within 3 to 12 months occurred significantly more frequently in patients having tumors with both p53 aberrations ( p 〈 0.05). Thus, aberration of tumor‐suppressor genes was a frequent occurrence in esophageal squamous‐cell carcinoma and inactivation of the p53 gene may contribute to the progression of this tumor. © Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
DOI:
10.1002/ijc.2910570105
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
