In:
International Journal of Cancer, Wiley, Vol. 136, No. 8 ( 2015-04-15), p. 1845-1855
Abstract:
What's new? Altered DNA methylation in peripheral blood may be indicative of early‐stage breast cancer, but methylation signatures await validation. The present study is among the first to identify and validate decreased methylation at CpG site cg27091787 in the HYAL2 gene as a potential marker of breast cancer. Methylation levels at cg27091787 were inversely associated with HYAL2 expression and were found to be indicative of breast cancer stage, thus enabling discrimination of early‐stage disease, as well as facilitating disease detection in women under age 50. Differential methylation at cg27091787 could serve as a blood‐based marker for early breast cancer detection.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8