In:
International Journal of Cancer, Wiley, Vol. 136, No. 9 ( 2015-05), p. 2078-2090
Abstract:
What's new? Fatty acid synthase (FASN)—which is overexpressed in cancer and regulates oncogenic de‐novo‐lipogenesis—has been regarded as a marker of malignancy. Contrarily to the widely accepted concept that normal cells are negative for FASN, here the authors demonstrate that FASN is overexpressed in the ovarian system when cells reveal high growth rates, irrespective of their state of malignancy/differentiation/senescence. FASN thus represents a metabolic marker of ovarian cell proliferation rather than cancer. The study further shows that FASN is a useful cancer target, since quiescent normal cells usually lack it and the few positive dividing normal cells are spared by FASN‐drugs.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8