In:
International Journal of Cancer, Wiley, Vol. 136, No. 11 ( 2015-06), p. 2693-2704
Abstract:
What's new? The nuclear bile acid receptor FXR has been shown to exert tumor‐protective functions in the liver and intestine. This study provides evidence that the liver‐derived plasma protein and tumor suppressor histidine‐rich glycoprotein (HRG) is a novel and most likely direct transcriptional target gene of FXR. Plasma HRG levels in healthy male volunteers increased 1.6‐fold after daily administration of 0.5 mg/kg of the non‐steroidal FXR agonist PX20606 for seven days, raising the possibility that potent FXR agonists might be beneficial in serious health conditions with reduced HRG such as hepatocellular carcinoma but also other solid cancers, liver failure, sepsis, and preeclampsia.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
