In:
International Journal of Cancer, Wiley, Vol. 136, No. 11 ( 2015-06), p. 2524-2534
Kurzfassung:
What's new? The purpose of this study was to explore the mechanisms of angiogenic microenvironment formation using EGFRvIII‐positive glioblastoma as a model. EGFRvIII is regarded as a poor prognosis marker in gliomas because of its potential to confer enhanced tumorigenicity. Here, the authors confirm that EGFRvIII promotes a more malignant microenvironment in mice, as demonstrated by greater expression of the pro‐angiogenic and tumorigenic factor VEGF. C/EBPβ‐mediated regulation of IL‐6 is indispensable for maintenance of this angiogenic microenvironment. In contrast, the drug genistein inhibits the development of tumor angiogenesis through a mechanism involving CHOP‐mediated inhibition of C/EBPβ and the subsequent down‐regulation of IL‐6.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
218257-9
ZDB Id:
1474822-8