In:
International Journal of Cancer, Wiley, Vol. 136, No. 12 ( 2015-06-15), p. 2799-2810
Abstract:
What's new? Mutations and alterations in the expression and activity of CK1 isoforms‐‐which play important roles in many cellular processes‐‐are known to contribute to tumorigenesis and tumor progression. The authors show that expression of CK1ɛ correlates with the survival of colorectal cancer patients. Furthermore, they identify CK1δ mutations leading to altered kinetic parameters in vitro and, when introduced into a carcinoma cell line, altered tumor growth in vivo. Since the mutant with high oncogenic potential also displays greater sensitivity to CK1‐specific inhibitors, the findings underline the potential use of CK1‐specific inhibitors in the treatment of colorectal cancer and personalized medicine.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
